In the past twenty years hundreds of infants and young children have died after being left in vehicles, usually by accident. When turning the vehicle off, drivers of the E-Class Sedan are reminded to check the back seat if they opened the rear door before starting out. The A6 doesn’t offer a back seat reminder.
The E-Class Sedan has a standard blind spot warning system that uses sensors to alert the driver to objects in the vehicle’s blind spots where the side view mirrors don’t reveal them. A system to reveal vehicles in the A6’s blind spot costs extra.
To help make backing out of a parking space safer, the E-Class Sedan has standard Rear Cross-Traffic Alert and Active Brake Assist automatically engages the brakes to help avoid a collision. Audi charges extra for Rear Cross-Traffic Assist on the A6.
The E-Class Sedan’s driver alert monitor detects an inattentive driver then sounds a warning and suggests a break. According to the NHTSA, drivers who fall asleep cause about 100,000 crashes and 1500 deaths a year. The A6 doesn’t offer a driver alert monitor.
Both the E-Class Sedan and the A6 have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, all wheel drive, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, rearview cameras and available lane departure warning systems.

